Spruce Avenue’s central location has attracted an impressive variety of land uses. The neighbourhood contains Kingsway Garden Mall, a regional shopping centre that competes with the downtown commercial district. A portion of the Northern Alberta Institute of Technology (NAIT) campus is located within the neighbourhood. The Municipal Airport is located just to the northwest of the neighbourhood. The neighbourhood also contains the Glenrose Hospital (the original Royal Alexandra), one of Edmonton’s largest until its replacement was built south of 111 Avenue.

Namayo Avenue (97th Street) and 1st Street (101st Street) were principal thoroughfares for people traveling between Edmonton’s downtown and destinations to the north. As a result, the neighbourhood’s oldest residences are located along these streets. Newer residences are situated in the western portion of the neighbourhood. 97th Street remains one of Edmonton’s most important north–south thoroughfares today, and it connects northern Edmonton neighbourhoods with the city centre.

The residential section of the neighbourhood is oriented along gridiron streets lined with mature elm trees. A central school and park site anchors the residential community, and it is separated by several blocks on each side from non-residential land use. Residents have access to a variety of services within the immediate vicinity, as well as excellent access to other parts of the city via the major arterial roads that surround the community. In addition to homes and major institutional and commercial facilities, the neighbourhood also contains four schools and six places of worship.

The neighbourhood takes its name from the former designation for 114th Avenue, which was 114th Avenue-Spruce Avenue. The avenue was likely named after the spruce tree, which is native to the area.